| Rank | Film Title | Release Date | Domestic Gross |
| 1 | Titanic | 12/19/97 | $600,788,188 |
| 2 | Star Wars | 5/25/77 | $460,998,007 |
| 3 | Shrek 2 | 5/19/04 | $441,226,247 |
| 4 | E.T. the Extra-Terrestrial | 6/11/82 | $435,110,554 |
| 5 | Star Wars: Episode I — The Phantom Menace | 5/19/99 | $431,088,301 |
| 6 | Pirates of the Caribbean: Dead Man's Chest | 7/7/06 | $421,060,364 |
| 7 | Spider-Man | 5/3/02 | $403,706,375 |
| 8 | Star Wars: Episode III — Revenge of the Sith | 5/19/05 | $380,270,577 |
| 9 | The Lord of the Rings: The Return of the King | 12/17/03 | $377,027,325 |
| 10 | Spider-Man 2 | 6/30/04 | $373,585,825 |
| 11 | The Passion of the Christ | 2/25/04 | $370,782,930 |
| 12 | Jurassic Park | 6/11/93 | $357,067,947 |
| 13 | The Lord of the Rings: The Two Towers | 12/18/02 | $341,786,758 |
| 14 | Finding Nemo | 5/30/03 | $339,714,978 |
| 15 | Forrest Gump | 7/6/94 | $329,694,499 |
| 16 | The Lion King | 6/15/94 | $328,541,776 |
| 17 | Harry Potter and the Sorcerer's Stone | 11/16/01 | $317,575,550 |
| 18 | The Lord of the Rings: The Fellowship of the Ring | 12/19/01 | $314,776,170 |
| 19 | Star Wars: Episode II — Attack of the Clones | 5/16/02 | $310,676,740 |
| 20 | Return of the Jedi | 5/25/83 | $309,306,177 |
| 21 | Independence Day | 7/3/96 | $306,169,268 |
| 22 | Pirates of the Caribbean: The Curse of the Black Pearl | 7/9/03 | $305,413,918 |
| 23 | The Sixth Sense | 8/6/99 | $293,506,292 |
| 24 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | 12/9/05 | $291,710,957 |
| 25 | The Empire Strikes Back | 5/21/80 | $290,475,067 |
| 26 | Harry Potter and the Goblet of Fire | 11/18/05 | $290,013,036 |
| 27 | Home Alone | 11/16/90 | $285,761,243 |
| 28 | The Matrix Reloaded | 5/15/03 | $281,576,461 |
| 29 | Meet the Fockers | 12/22/04 | $279,261,160 |
| 30 | Shrek | 5/16/01 | $267,665,011 |
| 31 | Harry Potter and the Chamber of Secrets | 11/15/02 | $261,988,482 |
| 32 | The Incredibles | 11/5/04 | $261,441,092 |
| 33 | Dr. Seuss' How the Grinch Stole Christmas | 11/17/00 | $260,044,825 |
| 34 | Jaws | 6/20/75 | $260,000,000 |
| 35 | Monsters, Inc. | 11/2/01 | $255,873,250 |
| 36 | Batman | 6/23/89 | $251,188,924 |
| 37 | Men in Black | 7/2/97 | $250,690,539 |
| 38 | Harry Potter and the Prisoner of Azkaban | 6/4/04 | $249,541,069 |
| 39 | Toy Story 2 | 11/19/99 | $245,852,179 |
| 40 | Cars | 6/9/06 | $244,052,771 |
| 41 | Bruce Almighty | 5/23/03 | $242,829,261 |
| 42 | Raiders of the Lost Ark | 6/12/81 | $242,374,454 |
| 43 | Twister | 5/10/96 | $241,721,524 |
| 44 | My Big Fat Greek Wedding | 4/19/02 | $241,438,208 |
| 45 | Ghostbusters | 6/8/84 | $238,632,124 |
| 46 | Beverly Hills Cop | 12/5/84 | $234,760,478 |
| 47 | X-Men: The Last Stand | 5/26/06 | $234,362,462 |
| 48 | War of the Worlds | 6/29/05 | $234,280,354 |
| 49 | Cast Away | 12/22/00 | $233,632,142 |
| 50 | The Exorcist | 12/26/73 | $232,671,011 |
| 51 | The Lost World | 5/22/97 | $229,086,679 |
| 52 | Signs | 8/2/02 | $227,966,634 |
| 53 | Rush Hour 2 | 8/3/01 | $226,164,286 |
| 54 | Mrs. Doubtfire | 11/24/93 | $219,195,243 |
| 55 | King Kong | 12/14/05 | $218,080,025 |
| 56 | Ghost | 7/13/90 | $217,631,306 |
| 57 | The Da Vinci Code | 5/19/06 | $217,536,138 |
| 58 | Aladdin | 11/13/92 | $217,350,219 |
| 59 | Saving Private Ryan | 7/24/98 | $216,540,909 |
| 60 | Mission: Impossible II | 5/24/00 | $215,409,889 |
| 61 | X2: X-Men United | 5/2/03 | $214,949,694 |
| 62 | Austin Powers in Goldmember | 7/26/02 | $213,307,889 |
| 63 | Back to the Future | 7/3/85 | $210,609,762 |
| 64 | The Wedding Crashers | 7/15/05 | $209,255,921 |
| 65 | Charlie and the Chocolate Factory | 7/15/05 | $206,459,076 |
| 66 | Austin Powers: The Spy Who Shagged Me | 6/11/99 | $206,040,086 |
| 67 | Batman Begins | 6/15/05 | $205,343,774 |
| 68 | Terminator 2: Judgment Day | 7/3/91 | $204,843,345 |
| 69 | The Mummy Returns | 5/4/01 | $202,019,785 |
| 70 | Armageddon | 7/1/98 | $201,578,182 |
| 71 | Superman Returns | 6/28/06 | $199,806,686 |
| 72 | Gone With the Wind | 12/15/39 | $198,676,459 |
| 73 | Pearl Harbor | 5/25/01 | $198,542,554 |
| 74 | Indiana Jones and the Last Crusade | 5/24/89 | $197,171,806 |
| 75 | Ice Age: The Meltdown | 3/31/06 | $195,330,621 |
| 76 | Madagascar | 5/27/05 | $193,595,521 |
| 77 | Toy Story | 11/22/95 | $191,796,233 |
| 78 | Men in Black II | 7/3/02 | $190,418,803 |
| 79 | Grease | 6/16/78 | $188,389,888 |
| 80 | Gladiator | 5/5/00 | $187,705,427 |
| 81 | The Day After Tomorrow | 5/28/04 | $186,740,799 |
| 82 | Mr. and Mrs. Smith | 6/10/05 | $186,336,279 |
| 83 | Snow White and the Seven Dwarfs | 12/21/37 | $184,925,486 |
| 84 | Dances With Wolves | 11/9/90 | $184,208,848 |
| 85 | Batman Forever | 6/16/95 | $184,031,112 |
| 86 | The Fugitive | 8/6/93 | $183,875,760 |
| 87 | Ocean's Eleven | 12/7/01 | $183,417,150 |
| 88 | What Women Want | 12/15/00 | $182,811,707 |
| 89 | The Perfect Storm | 6/30/00 | $182,618,434 |
| 90 | Liar Liar | 3/21/97 | $181,410,615 |
| 91 | Jurassic Park III | 7/18/01 | $181,171,875 |
| 92 | Mission: Impossible | 5/22/96 | $180,981,856 |
| 93 | Planet of the Apes | 7/27/01 | $180,011,740 |
| 94 | Indiana Jones and the Temple of Doom | 5/23/84 | $179,870,271 |
| 95 | Hitch | 2/11/05 | $179,495,555 |
| 96 | Pretty Woman | 3/23/90 | $178,406,268 |
| 97 | Tootsie | 12/17/82 | $177,200,000 |
| 98 | Top Gun | 5/16/86 | $176,786,701 |
| 99 | There's Something About Mary | 7/15/98 | $176,484,651 |
| 100 | Ice Age | 3/15/02 | $176,387,405 |
| 101 | The Bourne Supremacy | 7/23/04 | $176,241,941 |
| 102 | Crocodile Dundee | 9/26/86 | $174,803,506 |
| 103 | Apollo 13 | 6/30/95 | $173,837,933 |
| 104 | The Polar Express | 11/10/04 | $173,675,955 |
| 105 | Home Alone 2: Lost in New York | 11/20/92 | $173,585,516 |
| 106 | Elf | 11/7/03 | $173,398,518 |
| 107 | National Treasure | 11/19/04 | $173,008,894 |
| 108 | Air Force One | 7/25/97 | $172,956,409 |
| 109 | Rain Man | 12/16/88 | $172,825,435 |
| 110 | The Matrix | 3/31/99 | $171,479,930 |
| 111 | Beauty and the Beast | 11/15/91 | $171,350,553 |
| 112 | Tarzan | 6/16/99 | $171,091,819 |
| 113 | A Beautiful Mind | 12/21/01 | $170,742,341 |
| 114 | Chicago | 12/27/02 | $170,687,518 |
| 115 | Three Men and a Baby | 11/25/87 | $167,780,960 |
| 116 | Meet the Parents | 10/6/00 | $166,244,045 |
| 117 | Robin Hood: Prince of Thieves | 6/14/91 | $165,493,908 |
| 118 | Hannibal | 2/9/01 | $165,092,268 |
| 119 | Catch Me if You Can | 12/25/02 | $164,615,351 |
| 120 | Big Daddy | 6/25/99 | $163,479,795 |
| 121 | Batman Returns | 6/19/92 | $162,831,698 |
| 122 | A Bug's Life | 11/20/98 | $162,798,565 |
| 123 | The Waterboy | 11/6/98 | $161,491,646 |
| 124 | Die Another Day | 11/22/02 | $160,942,139 |
| 125 | Shark Tale | 10/1/04 | $160,861,908 |
| 126 | The Sound of Music | 3/2/65 | $158,671,368 |
| 127 | The Firm | 7/2/93 | $158,348,367 |
| 128 | The Longest Yard | 5/27/05 | $158,119,460 |
| 129 | X-Men | 7/14/00 | $157,299,717 |
| 130 | Scary Movie | 7/7/00 | $157,019,771 |
| 131 | Fatal Attraction | 9/18/87 | $156,645,693 |
| 132 | Who Framed Roger Rabbit | 6/24/88 | $156,452,370 |
| 133 | The Sting | 12/25/73 | $156,000,000 |
| 134 | What Lies Beneath | 7/21/00 | $155,464,351 |
| 135 | The Mummy | 5/7/99 | $155,385,488 |
| 136 | Over the Hedge | 5/19/06 | $155,019,340 |
| 137 | Fantastic Four | 7/8/05 | $154,696,080 |
| 138 | Jerry Maguire | 12/13/96 | $153,952,592 |
| 139 | Beverly Hills Cop II | 5/20/87 | $153,665,036 |
| 140 | Scooby-Doo | 6/14/02 | $153,294,164 |
| 141 | Gremlins | 6/8/84 | $153,083,102 |
| 142 | Runaway Bride | 7/30/99 | $152,257,509 |
| 143 | Rambo: First Blood, Part II | 5/22/85 | $150,415,432 |
| 144 | Terminator 3: Rise of the Machines | 7/2/03 | $150,371,112 |
| 145 | As Good as It Gets | 12/23/97 | $148,478,011 |
| 146 | Talladega Nights: The Ballad of Ricky Bobby | 8/4/06 | $148,213,377 |
| 147 | Lethal Weapon 2 | 7/7/89 | $147,253,986 |
| 148 | True Lies | 7/15/94 | $146,282,411 |
| 149 | Lilo & Stitch | 6/21/02 | $145,794,338 |
| 150 | American Pie 2 | 8/10/01 | $145,103,595 |